$LLY · Eli Lilly and Company

This Form 4 filing reports a change in beneficial ownership by Juan R. Luciano, a director of Eli Lilly and Company. On October 19, 2026, Luciano acquired 12.8325 shares of Eli Lilly common stock at a price of $1,240.34 per share. The shares were received in lieu of cash compensation and, at his election, were deferred as stock units under the Lilly Directors’ Deferral Plan. Those deferred stock units will be settled in shares of common stock following his separation from service.

After the reported transaction, Luciano directly held 16,969.6463 shares of Eli Lilly common stock. The filing was signed on October 20, 2026 by an attorney-in-fact on his behalf.